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HRID1044368

反应详情

EQUATION

反应方程式

HRID 1044368 的结构方程式

REACTANTS

反应物

5
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：C1COCCO1
HCID31275

1,4-Dioxane

C4H8O2

结构：Cc1cnccc1Br
HCID428351

4-Bromo-3-methylpyridine

C6H6BrN

结构：CN[C@H]1CCCC[C@@H]1NC
HCID13822957

(1S,2S)-N~1~,N~2~-Dimethylcyclohexane-1,2-diamine

C8H18N2

结构：O=C1NCCC12CCCN(c1ccc(C(F)(F)F)cn1)C2
HCID66722301

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cnccc1N1CCC2(CCCN(c3ccc(C(F)(F)F)cn3)C2)C1=O
HCID57970788

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：[Cu][I]
催化剂HCID24350

Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

CuI

CONDITIONS

反应条件

温度
100 °C

PROCEDURE

实验过程

To a solution of 7-[5-(trifluoromethyl)pyridin-2-yl]-2,7-diazaspiro[4.5]decan-1-one (24.4 mg, 0.0000814 mol) in 1,4-dioxane (0.5 mL, 0.006 mol) were added (1S,2S)-N,N′-dimethylcyclohexane-1,2-diamine (2.3 mg, 0.000016 mol), copper(I) iodide (1.6 mg, 0.0000081 mol), 4-bromo-3-methylpyridine (28 mg, 0.00016 mol) and potassium carbonate (23.6 mg, 0.000171 mol); and the mixture was stirred at 100° C. overnight. The product was purified by prep-HPLC. LC-MS: 391.2 (M+H)+.

WORKUP

后处理

  1. customThe product was purified by prep-HPLC