Hydrochloric Acid → Ethyl 3-(2-[(4-methylpyridin-3-yl)amino]ethyl}piperidine-3-carboxylate trihydrochloride

HRID 1044370Notes

Reaction equation

HRID 1044370 reaction equation
[ClH:1].[CH3:2][C:3]1[CH:8]=[CH:7][N:6]=[CH:5][C:4]=1[NH:9][CH2:10][CH2:11][C:12]1([C:25]([O:27][CH2:28][CH3:29])=[O:26])[CH2:17][CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13]1>O1CCOCC1.C(OCC)(=O)C>[ClH:1].[ClH:1].[ClH:1].[CH3:2][C:3]1[CH:8]=[CH:7][N:6]=[CH:5][C:4]=1[NH:9][CH2:10][CH2:11][C:12]1([C:25]([O:27][CH2:28][CH3:29])=[O:26])[CH2:17][CH2:16][CH2:15][NH:14][CH2:13]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 667226241-Tert-butyl 3-ethyl 3-{2-[(4-methylpyridin-3-yl)amino]ethyl}piperidine-1,3-dicarboxylate

Product 1

HCID 66722530Ethyl 3-(2-[(4-methylpyridin-3-yl)amino]ethyl}piperidine-3-carboxylate trihydrochloride

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Procedure

Hydrogen chloride in 1,4-dioxane (4.0 M, 2.0 mL) was added to a solution of 1-tert-butyl 3-ethyl 3-{2-[(4-methylpyridin-3-yl)amino]ethyl}piperidine-1,3-dicarboxylate (0.036 g, 0.000092 mol) in ethyl acetate (0.5 mL) and the mixture was stirred for 2 h. Then the solvent was removed in-vacuo to afford the product. LC-MS: 292.3 (M+H)+.

Workup

  1. customThen the solvent was removed in-vacuo
  2. customto afford the product

Sources & evidence

ORD record
ord-8348cc4cb11d45b091c69b634dd840ab
Source dataset
uspto-grants-2013_10
Patent number
US08563570B2

Reaction notes

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