Hydrochloric Acid → HCID 68513475, compound

HRID 1044457Notes

Reaction equation

HRID 1044457 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[C:15]([C:16](=[O:18])[CH:17]=2)=[C:14]([OH:19])[CH:13]=[C:12]([OH:20])[C:11]=3[C@@H:21]2[CH2:25][CH2:24][N:23]([CH3:26])[C@H:22]2[CH2:27][OH:28])=[C:4]([Cl:29])[CH:3]=1.Cl>CO>[ClH:29].[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[C:15]([C:16](=[O:18])[CH:17]=2)=[C:14]([OH:19])[CH:13]=[C:12]([OH:20])[C:11]=3[C@@H:21]2[CH2:25][CH2:24][N:23]([CH3:26])[C@H:22]2[CH2:27][OH:28])=[C:4]([Cl:29])[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68513476HCID 68513476, compound

Product 1

HCID 68513475HCID 68513475, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The compound (+)-trans-2-(4-Amino-2-chlorophenyl)-5,7-dihydroxy-8-(2-hydroxymethyl-1-methylpyrrolidin-3-yl)-chromen-4-one (0.25 g, 0.6 mmol) was suspended in methanol (2 mL) and treated with ethereal HCl and the organic solvent evaporated to yield the compound, (+)-trans-2-(4-amino-2-chloro phenyl)-5,7-dihydroxy-8-(2-hydroxymethyl-1-methylpyrrolidin-3-yl)-chromen-4-one hydrochloride.

Workup

  1. customthe organic solvent evaporated

Sources & evidence

ORD record
ord-c4e138402d284d8689131eb026df6f34
Source dataset
uspto-grants-2013_10
Patent number
US08563596B2

Reaction notes

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