Hydrochloric Acid → HCID 68515008, compound

HRID 1044458Notes

Reaction equation

HRID 1044458 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][CH3:9])[CH:5]=[CH:4][C:3]=1[C:10]1[O:11][C:12]2[C:17]([C:18](=[O:20])[CH:19]=1)=[C:16]([OH:21])[CH:15]=[C:14]([OH:22])[C:13]=2[C@@H:23]1[CH2:27][CH2:26][N:25]([CH3:28])[C@H:24]1[CH2:29][OH:30].Cl>CO>[ClH:1].[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][CH3:9])[CH:5]=[CH:4][C:3]=1[C:10]1[O:11][C:12]2[C:17]([C:18](=[O:20])[CH:19]=1)=[C:16]([OH:21])[CH:15]=[C:14]([OH:22])[C:13]=2[C@@H:23]1[CH2:27][CH2:26][N:25]([CH3:28])[C@H:24]1[CH2:29][OH:30]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68515009HCID 68515009, compound

Product 1

HCID 68515008HCID 68515008, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The compound, (+)-trans-2-(2-Chloro-4-methylamino-phenyl)-5,7-dihydroxy-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-chromen-4-one (0.13 g, 0.3 mmol) was suspended in methanol (2 mL) and treated with ethereal HCl and the organic solvent evaporated to obtain the salt, (+)-trans-2-(2-chloro-4-methylaminophenyl)-5,7-dihydroxy-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-chromen-4-one hydrochloride.

Workup

  1. customthe organic solvent evaporated

Sources & evidence

ORD record
ord-2f68ed1944d24868b212d88989a1bb62
Source dataset
uspto-grants-2013_10
Patent number
US08563596B2

Reaction notes

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