Hydrochloric Acid → 7-Amino-8-(4-chlorobenzyl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile hydrochloride

HRID 1044488Notes

Reaction equation

HRID 1044488 reaction equation
[Cl:1][C:2]1[CH:28]=[CH:27][C:5]([CH2:6][CH:7]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:17]#[N:18])[CH:15]=3)[CH2:10][CH2:9][CH:8]2[NH:19]C(=O)OC(C)(C)C)=[CH:4][CH:3]=1.Cl>ClCCl.C(O)(C)C>[ClH:1].[NH2:19][CH:8]1[CH:7]([CH2:6][C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:28][CH:27]=2)[C:16]2[CH:15]=[C:14]([C:17]#[N:18])[CH:13]=[CH:12][C:11]=2[CH2:10][CH2:9]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57471190HCID 57471190, compound

Product 1

HCID 574711857-Amino-8-(4-chlorobenzyl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile hydrochloride

Reagents, catalysts & solvents 2

HCID 3776IsopropanolSolventHCID 6344DichloromethaneSolvent

Procedure

Tert-butyl [1-(4-chlorobenzyl)-7-cyano-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate (15 mg, 0.038 mmol) was dissolved in dichloromethane (1.5 mL) and 5 M hydrochloric acid in isopropanol (0.3 mL) was added. The reaction mixture was stirred for 3 h at room temperature. The solvent and the excess hydrochloric acid were evaporated in vacuo. Yield: 11 mg (0.033 mmol, 87%, colorless solid).

Workup

  1. customThe solvent and the excess hydrochloric acid were evaporated in vacuo

Sources & evidence

ORD record
ord-c825ead4be804e209e63cb58627278c3
Source dataset
uspto-grants-2013_10
Patent number
US08563617B2

Reaction notes

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