反应详情

Tert-butyl 1-benzyl-7-cyano-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (1.1 g, 3.03 mmol) was dissolved in dichloromethane (20 mL) and 5 M hydrochloric acid in isopropanol (2 mL) was added. The reaction mixture was stirred at room temperature for 12 h followed by 4 h at 35° C. The solvent was evaporated in vacuo. Water (30 mL) was added and the pH was adjusted to pH 9 using aqueous saturated sodium bicarbonate solution. The aqueous layer was extracted with dichloromethane. The combined extracts were dried (MgSO4) and the solvent was evaporated in vacuo. Yield: 790 mg (3.03 mmol, 100%).

1. waitfollowed by 4 h at 35° C
2. customThe solvent was evaporated in vacuo
3. additionWater (30 mL) was added
4. extractionThe aqueous layer was extracted with dichloromethane
5. dry with materialThe combined extracts were dried (MgSO4)
6. customthe solvent was evaporated in vacuo