Nitrogen → 5-Nitro-2-pentanone

HRID 1044731Notes

Reaction equation

HRID 1044731 reaction equation
N#N.[CH:3]([C:5]([CH3:7])=[O:6])=[CH2:4].[N+:8]([CH3:11])([O-:10])=[O:9]>>[N+:8]([CH2:11][CH2:4][CH2:3][C:5](=[O:6])[CH3:7])([O-:10])=[O:9]

Participants

4

Reactant 3

HCID 947NitrogenHCID 6375NitromethaneHCID 6570Methyl vinyl ketone

Product 1

HCID 42950035-Nitro-2-pentanone

Procedure

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), to a solution of methyl vinyl ketone (2.32 mL, 28.53 mmol) in nitromethane (29.6 mL) was added activated KF/Al2O3 (323 mg, prepared by mixing KF and basic Al2O3 in water followed by concentrating and drying) at 0° C. The reaction mixture was then allowed to warm up to rt and stirred at this temperature for 18 h. The mixture was filtered through neutral Al2O3 and washed with CH2Cl2. The filtrated was concentrated under reduced pressure to give the title compound as a colorless oil.

Workup

  1. additionwas added
  2. customat 0° C
  3. filtrationThe mixture was filtered through neutral Al2O3
  4. washwashed with CH2Cl2
  5. concentrationThe filtrated was concentrated under reduced pressure

Sources & evidence

ORD record
ord-0d2573c018274854b4e6e64fdc1082d6
Source dataset
uspto-grants-2013_10
Patent number
US08563714B2

Reaction notes

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