Acetone → N-Isopropylcyclopentanamine

HRID 10448Notes

Reaction equation

HRID 10448 reaction equation
[CH:1]1([NH2:6])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:7][C:8]([CH3:10])=O>[OH-].[OH-].[Pd+2]>[CH:8]([NH:6][CH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1)([CH3:10])[CH3:7]

Participants

4

Reactant 2

HCID 180AcetoneHCID 2906Cyclopentylamine

Product 1

HCID 17750362N-Isopropylcyclopentanamine

Reagents, catalysts & solvents 1

HCID 9942167Palladium hydroxideCatalyst

Procedure

Peariman's catalyst (20% w/w palladium hydroxide-on-carbon) (1.5 g) was added to a solution of cyclopentylamine (15 ml, 0.21 mol) in acetone (200 ml). The reaction mixture was stirred under an atmosphere of hydrogen gas at 414 kPa (60 psi). After stirring for 16 hours the reaction mixture was filtered through Arbocel (trade mark) and the solvent removed under reduced pressure to give the title compound (15 ml) as a thin oil.

Workup

  1. stirringAfter stirring for 16 hours the reaction mixture
  2. filtrationwas filtered through Arbocel (trade mark)
  3. customthe solvent removed under reduced pressure

Sources & evidence

ORD record
ord-a37b355baf0d4ccb87189a29d7e7e818
Source dataset
uspto-grants-2006_08
Patent number
US07094769B2

Reaction notes

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