Nitrogen → HCID 178511559, compound

HRID 1044814Notes

Reaction equation

HRID 1044814 reaction equation
N#N.C(OC([NH:13][C@@H:14]1[CH2:19][CH2:18][C@H:17]([CH2:20][OH:21])[CH2:16][CH2:15]1)=O)C1C=CC=CC=1>CO.[Pd]>[NH2:13][C@@H:14]1[CH2:19][CH2:18][C@H:17]([CH2:20][OH:21])[CH2:16][CH2:15]1

Participants

5

Reactant 2

HCID 947NitrogenHCID 178523768HCID 178523768, compound

Product 1

HCID 178511559HCID 178511559, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of cis-4-benzyloxycarbonylaminocyclohexane-methanol (235 mg, 0.89 mmol) in MeOH (5 mL) was hydrogenated in the presence of Pd/C (10%) at rt until completion of the reaction. The mixture was then filtered and concentrated under reduced pressure. The title compound was obtained as a colorless oil. LC-MS-conditions 07: tR=0.12 min; [M+H]+=130.26.

Workup

  1. filtrationThe mixture was then filtered
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-2e1e6159d2ac4cabb819fe16c45eb6a2
Source dataset
uspto-grants-2013_10
Patent number
US08563714B2

Reaction notes

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