Hydrazine hydrate (1:1) → HCID 67118448, compound

HRID 1044823Notes

Reaction equation

HRID 1044823 reaction equation
[F:1][C:2]([F:32])([F:31])[O:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:13]2[CH2:18][CH2:17][CH:16]([O:19][N:20]3C(=O)C4C(=CC=CC=4)C3=O)[CH2:15][CH2:14]2)(=[O:12])=[O:11])=[CH:6][CH:5]=1.O.NN>CCO>[F:32][C:2]([F:1])([F:31])[O:3][C:4]1[CH:5]=[CH:6][C:7]([S:10]([N:13]2[CH2:18][CH2:17][CH:16]([O:19][NH2:20])[CH2:15][CH2:14]2)(=[O:11])=[O:12])=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 67118409HCID 67118409, compound

Product 1

HCID 67118448HCID 67118448, compoundYield 112.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yloxy)isoindoline-1,3-dione (640 mg, 1.36 mmol) and hydrazine monohydrate (0.073 ml, 1.5 mmol) in EtOH (6 ml) was stirred for 1 hour. The precipitated materials were filtered off and washed with EtOH (2 ml×2), then the filtrate was evaporated under reduced pressure to give O-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yl)hydroxylamine (519 mg, 100%).

Workup

  1. filtrationThe precipitated materials were filtered off
  2. washwashed with EtOH (2 ml×2)
  3. customthe filtrate was evaporated under reduced pressure

Sources & evidence

ORD record
ord-f3212f78d9824ae3b8dc2b733ae2389a
Source dataset
uspto-grants-2013_10
Patent number
US08563732B2

Reaction notes

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