Dimethylformamide → HCID 67043412, compound

HRID 1045036Notes

Reaction equation

HRID 1045036 reaction equation
[F:1][C:2]1[C:10]2[S:9](=[O:12])(=[O:11])[NH:8][C:7](=O)[C:6]=2[CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:16])=O.CN(C=O)C>O1CCOCC1>[Cl:16][C:7]1[C:6]2[CH:5]=[CH:4][CH:3]=[C:2]([F:1])[C:10]=2[S:9](=[O:12])(=[O:11])[N:8]=1

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 670433231197362-78-9

Product 1

HCID 67043412HCID 67043412, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3.02 g of 7-fluoro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide (EP291851 A2 19881123), 1.64 ml of thionyl chloride and a catalytic amount of DMF in 13 ml of dioxane are heated under reflux for 45 hours. The mixture is concentrated and the residue is crystallized in toluene. 2.50 g of a crude solid is obtained.

Workup

  1. temperatureunder reflux for 45 hours
  2. concentrationThe mixture is concentrated
  3. customthe residue is crystallized in toluene

Sources & evidence

ORD record
ord-869dec3189574e918d0be4123a0eb1d1
Source dataset
uspto-grants-2013_10
Patent number
US08563744B2

Reaction notes

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