3-(5-Methyl-1,2,4-oxadiazol-3-yl)phenyl acetate → 3-(5-Methyl-1,2,4-oxadiazol-3-yl)phenol

HRID 1045373Notes

Reaction equation

HRID 1045373 reaction equation
C([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]2[N:15]=[C:14]([CH3:16])[O:13][N:12]=2)[CH:6]=1)(=O)C>Cl>[CH3:16][C:14]1[O:13][N:12]=[C:11]([C:7]2[CH:6]=[C:5]([OH:4])[CH:10]=[CH:9][CH:8]=2)[N:15]=1

Participants

3

Reactant 1

HCID 667979553-(5-Methyl-1,2,4-oxadiazol-3-yl)phenyl acetate

Product 1

HCID 120425193-(5-Methyl-1,2,4-oxadiazol-3-yl)phenol

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 8.55 g (39.18 mmol) of the product obtained in Step C above in 120 ml of 1N HCl solution is heated at reflux for 90 minutes and is then left at ambient temperature overnight, with stirring. The precipitate is filtered off to yield the title product.

Workup

  1. temperatureat reflux for 90 minutes
  2. filtrationThe precipitate is filtered off

Sources & evidence

ORD record
ord-10a488ae5abf4fc5897e9468539c7837
Source dataset
uspto-grants-2013_10
Patent number
US08569285B2

Reaction notes

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