p-Toluenesulfonic acid → HCID 19703103, compound

HRID 1045378Notes

Reaction equation

HRID 1045378 reaction equation
[C:1]([O:4][N:5]=[C:6]([C:8]1[CH:13]=[CH:12][C:11]([I:14])=[CH:10][CH:9]=1)[NH2:7])(=O)[CH3:2].C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[I:14][C:11]1[CH:12]=[CH:13][C:8]([C:6]2[N:7]=[C:1]([CH3:2])[O:4][N:5]=2)=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 86663308N'-(acetyloxy)-4-iodobenzenecarboximidamide

Product 1

HCID 19703103HCID 19703103, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a solution of the product obtained in Step B above (9.7 g, 31.9 mmol) in 300 ml of toluene there are added 150 mg of para-toluenesulphonic acid and the reaction mixture is heated at reflux, using a Dean-Stark installation, for 24 hours. The mixture is evaporated to dryness and dried using a vacuum pump.

Workup

  1. temperaturethe reaction mixture is heated
  2. temperatureat reflux
  3. customThe mixture is evaporated to dryness
  4. customdried

Sources & evidence

ORD record
ord-1c06c3c2da6c4d7fbe4542b0c33f260c
Source dataset
uspto-grants-2013_10
Patent number
US08569285B2

Reaction notes

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