Triethylamine → HCID 66789652, compound

HRID 1045383Notes

Reaction equation

HRID 1045383 reaction equation
Cl.[Cl:2][CH2:3][CH2:4][NH2:5].C(N(CC)CC)C.[Br:13][C:14]1[CH:15]=[CH:16][C:17]([O:24][CH3:25])=[C:18]([S:20](Cl)(=[O:22])=[O:21])[CH:19]=1>C(Cl)Cl>[Br:13][C:14]1[CH:15]=[CH:16][C:17]([O:24][CH3:25])=[C:18]([S:20]([NH:5][CH2:4][CH2:3][Cl:2])(=[O:21])=[O:22])[CH:19]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 5200205-Bromo-2-methoxybenzene-1-sulfonyl chlorideHCID 97937372-Chloroethylamine hydrochloride

Product 1

HCID 66789652HCID 66789652, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a suspension of 13.4 g (0.115 mol) of 2-chloroethylamine hydrochloride in 150 ml of CH2Cl2 there are added 34 ml (0.241 mol) of triethylamine and then, dropwise, 30 g (0.105 mol) of the product obtained in Step A above dissolved in 200 ml of CH2Cl2. The solution is stirred for 2 hours at ambient temperature and is then washed with 1N HCl solution, water and brine. The organic phase is dried over MgSO4 and evaporated. The solid is re-suspended in ethyl ether and filtered off to yield the title product.

Workup

  1. washis then washed with 1N HCl solution, water and brine
  2. dry with materialThe organic phase is dried over MgSO4
  3. customevaporated
  4. filtrationfiltered off

Sources & evidence

ORD record
ord-0873650ad1b841a2bf45247149464d2d
Source dataset
uspto-grants-2013_10
Patent number
US08569285B2

Reaction notes

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