HCID 66797555, compound → HCID 56933438, compound

HRID 1045387Notes

Reaction equation

HRID 1045387 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:8]=[C:9]([CH:31]=[CH:32][CH:33]=2)[O:10][C:11]2[CH:30]=[CH:29][C:14]3[O:15][CH2:16][CH2:17][N:18](C(OC(C)(C)C)=O)[S:19](=[O:21])(=[O:20])[C:13]=3[CH:12]=2)[N:3]=1>Cl.O1CCOCC1>[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:8]=[C:9]([CH:31]=[CH:32][CH:33]=2)[O:10][C:11]2[CH:30]=[CH:29][C:14]3[O:15][CH2:16][CH2:17][NH:18][S:19](=[O:21])(=[O:20])[C:13]=3[CH:12]=2)[N:3]=1

Participants

4

Reactant 1

HCID 66797555HCID 66797555, compound

Product 1

HCID 56933438HCID 56933438, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of 1.92 g (4.05 mmol) of the product obtained in Step H above is heated at 80° C. for 2 hours in 15 ml of 4N HCl solution in dioxane. The mixture is evaporated to dryness and dried in vacuo. The crude product is purified by chromatography over silica gel eluting with a mixture of CH2Cl2/AcOEt. The solid is taken up in isopropyl ether and filtered to yield the title product.

Workup

  1. customThe mixture is evaporated to dryness
  2. customdried in vacuo
  3. customThe crude product is purified by chromatography over silica gel eluting with a mixture of CH2Cl2/AcOEt
  4. filtrationfiltered

Sources & evidence

ORD record
ord-2c5dba44408c464983e995c5a5765df1
Source dataset
uspto-grants-2013_10
Patent number
US08569285B2

Reaction notes

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