Hydrochloric Acid → 2-Amino-3,4-dihydronaphthalen-1(2H)-one--hydrogen chloride (1/1)

HRID 1045653Notes

Reaction equation

HRID 1045653 reaction equation
[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4][CH:3]1[NH:12]C(=O)C.[ClH:16]>>[ClH:16].[NH2:12][CH:3]1[CH2:4][CH2:5][C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2]1=[O:1]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 9859076HCID 9859076, compound

Product 1

HCID 124805352-Amino-3,4-dihydronaphthalen-1(2H)-one--hydrogen chloride (1/1)Yield 100%

Conditions

Temperature
100 °C

Procedure

N-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-acetamide (16.5 g, 81 mmol) was added to 3N aqueous hydrochloric acid (270 ml) and stirred at 100° C. for 5 hours. After removal of the solvent, the precipitate was filtered, washed with ethanol, and dried to give 2-amino-3,4-dihydro-2H-naphthalen-1-one hydrochloride (16.0 g, 81 mmol, 100%) as white crystals.

Workup

  1. customAfter removal of the solvent
  2. filtrationthe precipitate was filtered
  3. washwashed with ethanol
  4. customdried

Sources & evidence

ORD record
ord-fb5cffc5d4ed44b6b6e3b9215c0b67fa
Source dataset
uspto-grants-2013_10
Patent number
US08569294B2

Reaction notes

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