反应详情

To a solution of (S)-3-hydroxypyrrolidine-1-carboxylic acid tert-butyl ester (11 g, 57 mmol) and triethylamine (17.3 g, 171 mmol) in tetrahydrofuran (180 ml) was added methanesulfonyl chloride (9.8 g, 85.5 mmol) at 5° C. The mixture was stirred for 3 hours at room temperature, poured into water, and extracted with ethyl acetate. The organic extract was washed with brine and dried over sodium sulfate. The solvent was evaporated under reduced pressure to afford (S)-3-methanesulfonyloxypyrrolidine-1-carboxylic acid tert-butyl ester (16.9 g, quant.) as colorless oil.

1. extractionextracted with ethyl acetate
2. extractionThe organic extract
3. washwas washed with brine
4. dry with materialdried over sodium sulfate
5. customThe solvent was evaporated under reduced pressure