Hydrochloric Acid → HCID 22046467, compound

HRID 1045687Notes

Reaction equation

HRID 1045687 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][C@@H:10]([NH:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:9]1)=O)(C)(C)C.[ClH:21]>C(OCC)(=O)C>[ClH:21].[ClH:21].[CH2:14]([NH:13][CH:10]1[CH2:11][CH2:12][NH:8][CH2:9]1)[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57869945HCID 57869945, compound

Product 1

HCID 22046467HCID 22046467, compoundYield 51%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a solution of (R)-3-benzylaminopyrrolidine-1-carboxylic acid tert-butyl ester (15.3 g, 55.4 mmol) in ethyl acetate (100 ml) was added 12% hydrogen chloride in ethyl acetate (100 ml) at 5° C. The mixture was stirred for 2 hours at room temperature. The precipitated crystals were collected by filtration and washed with ethyl acetate to afford benzylpyrrolidin-3-yl-amine dihydrochloride (6.0 g, 51%) as colorless crystals.

Workup

  1. filtrationThe precipitated crystals were collected by filtration
  2. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-e85dfd8ea02545ac9b08aa25a7d09120
Source dataset
uspto-grants-2013_10
Patent number
US08569294B2

Reaction notes

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