反应详情

To a solution of 2-chloro-5-(1-ethoxyvinyl)pyrimidine (350 mg, 1.9 mmol) in THF (15 mL) was, added aqueous HCl (1N, 15 mL). The mixture was stirred at rt for 4 h, extracted with EtOAc. The organic phase was washed with satd aq NaHCO3 and brine. The combined organic layer was dried over anhydrous Na2SO4 and concentrated to give the crude product, which was purified by prep TLC (PE:EA 3:1) to give 1-(2-chloropyrimidin-5-yl)ethanone (268 mg, yield 90%).

1. extractionextracted with EtOAc
2. washThe organic phase was washed with satd aq NaHCO3 and brine
3. dry with materialThe combined organic layer was dried over anhydrous Na2SO4
4. concentrationconcentrated
5. customto give the crude product, which
6. customwas purified by prep TLC (PE:EA 3:1)