HRID1046397

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID67749

Trifluoromethanesulfonic anhydride

C2F6O5S2

结构：C#CCOc1ccc2c(c1)c(-c1ccc(C(C)C)cc1)nc(=O)n2CC(O)c1c(C)cc(C)cc1C

HCID59259156

未命名化合物

PRODUCTS

生成物

结构：C#CCOc1ccc2c(c1)c(-c1ccc(C(C)C)cc1)nc(=O)n2/C=C/c1c(C)cc(C)cc1C

HCID59259090

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID11

1,2-Dichloroethane

C2H4Cl2

PROCEDURE

实验过程

A solution of 50 mg (0.104 mmol) 1-[2-hydroxy-2-(2,4,6-trimethyl-phenyl)-ethyl]-4-(4-isopropyl-phenyl)-6-prop-2-ynyloxy-1H-quinazolin-2-one and 34.3 μl (0.208 mmol) trifluoromethane sulphonic anhydride in 0.5 ml 1,2 dichloroethane is heated to 80° C. for 15 min. Extraction with dichloromethane/aqueous NaHCO3 followed by preparative reversed phase HPLC yielded the title compound.

WORKUP

后处理

extractionExtraction with dichloromethane/aqueous NaHCO3

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-146e75c45cdb4860ba59f04fca6cada1
来源数据集: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08569317B2
来源说明: uspto-grants-2013_10

反应 SMILES

O[CH:2]([C:28]1[C:33]([CH3:34])=[CH:32][C:31]([CH3:35])=[CH:30][C:29]=1[CH3:36])[CH2:3][N:4]1[C:13]2[C:8](=[CH:9][C:10]([O:14][CH2:15][C:16]#[CH:17])=[CH:11][CH:12]=2)[C:7]([C:18]2[CH:23]=[CH:22][C:21]([CH:24]([CH3:26])[CH3:25])=[CH:20][CH:19]=2)=[N:6][C:5]1=[O:27].FC(F)(F)S(OS(C(F)(F)F)(=O)=O)(=O)=O>ClCCCl>[CH:24]([C:21]1[CH:22]=[CH:23][C:18]([C:7]2[C:8]3[C:13](=[CH:12][CH:11]=[C:10]([O:14][CH2:15][C:16]#[CH:17])[CH:9]=3)[N:4](/[CH:3]=[CH:2]/[C:28]3[C:29]([CH3:36])=[CH:30][C:31]([CH3:35])=[CH:32][C:33]=3[CH3:34])[C:5](=[O:27])[N:6]=2)=[CH:19][CH:20]=1)([CH3:25])[CH3:26]