Aminoacetaldehyde dimethyl acetal → HCID 178495885, compound

HRID 1046991Notes

Reaction equation

HRID 1046991 reaction equation
[N:1]1[C:6]2[NH:7][C:8]3[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=3[C:10](=S)[NH:11][C:5]=2[CH:4]=[CH:3][CH:2]=1.[CH3:17][O:18][CH:19]([O:22][CH3:23])[CH2:20][NH2:21]>>[CH3:17][O:18][CH:19]([O:22][CH3:23])[CH2:20][NH:21][C:10]1[C:9]2[CH:13]=[CH:14][CH:15]=[CH:16][C:8]=2[NH:7][C:6]2[N:1]=[CH:2][CH:3]=[CH:4][C:5]=2[N:11]=1

Participants

3

Reactant 2

HCID 89728Aminoacetaldehyde dimethyl acetalHCID 454962295,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepine-6-thione

Product 1

HCID 178495885HCID 178495885, compound

Conditions

Temperature
95 °C

Procedure

A mixture of 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepine-6-thione (3.21 g, 14 mmol) and 2,2-dimethoxyethylamine (7.6 mL, 70 mmol) was heated to 95° C. for 1 hour. After cooling to room temperature the solvent was evaporated in vacuo. The crude product was used in the next step without further purification.

Workup

  1. temperatureAfter cooling to room temperature the solvent
  2. customwas evaporated in vacuo
  3. customThe crude product was used in the next step without further purification

Sources & evidence

ORD record
ord-1ddb5d730f7a48b5a2e2bc5cae496d22
Source dataset
uspto-grants-2013_10
Patent number
US08569331B2

Reaction notes

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