Hydrochloric Acid → HCID 69621152, compound

HRID 1047127Notes

Reaction equation

HRID 1047127 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][C@@H:10]([N:14]2[C:23]3[C:18](=[CH:19][C:20]([C:24]4[CH:25]=[N:26][C:27]([NH:39][C:40]([NH:42][CH2:43][CH3:44])=[O:41])=[CH:28][C:29]=4[C:30]4[S:31][CH:32]=[C:33]([C:35]([F:38])([F:37])[F:36])[N:34]=4)=[CH:21][N:22]=3)[C:17](=[O:45])[C:16]([C:46]([O:48][CH2:49][CH3:50])=[O:47])=[CH:15]2)[CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[CH2:43]([NH:42][C:40](=[O:41])[NH:39][C:27]1[N:26]=[CH:25][C:24]([C:20]2[CH:19]=[C:18]3[C:23](=[N:22][CH:21]=2)[N:14]([C@@H:10]2[CH2:11][CH2:12][CH2:13][NH:8][CH2:9]2)[CH:15]=[C:16]([C:46]([O:48][CH2:49][CH3:50])=[O:47])[C:17]3=[O:45])=[C:29]([C:30]2[S:31][CH:32]=[C:33]([C:35]([F:37])([F:36])[F:38])[N:34]=2)[CH:28]=1)[CH3:44]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69621151HCID 69621151, compound

Product 1

HCID 69621152HCID 69621152, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of (R)-ethyl 1-(1-(tert-butoxycarbonyl)piperidin-3-yl)-6-(6-(3-ethylureido)-4-(4-(trifluoromethyl)thiazol-2-yl)pyridin-3-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate (300 mg) in dioxane (3 mL) was added 4 N HCl in dioxane (2 eq). The reaction mixture was stirred at room temperature overnight and the solid that formed was collected by filtration to provide the desired product.

Workup

  1. customthe solid that formed
  2. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-0eec15de987248a0b4999dfd3211e38c
Source dataset
uspto-grants-2013_10
Patent number
US08569484B2

Reaction notes

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