Hydrochloric Acid → HCID 3685898, compound

HRID 1047352Notes

Reaction equation

C1(N2CC[O:10]CC2)CCCCC=1.C(N(CC)CC)C.[C:20](Cl)(=[O:23])[CH2:21][CH3:22].Cl.[C:26]1(C)[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[C:20]([CH:27]1[CH2:28][CH2:29][CH2:30][CH2:31][C:26]1=[O:10])(=[O:23])[CH2:21][CH3:22]

Participants

Reactant 5

HCID 313Hydrochloric Acid

HCID 1140Toluene

HCID 8471Triethylamine

HCID 62324Propionyl chloride

HCID 69589Morpholine, 4-(1-cyclohexen-1-yl)-

Product 1

HCID 3685898HCID 3685898, compoundYield 49%

Procedure

Compound IVb is obtained in 49% yield as a colourless oil, according to Example 4, from 4-cyclohex-1-enyl-morpholine (82.64 g, 0.50 mol, obtained in Example 1), triethylamine (71.33 g, 1.41 mol), propionyl chloride (64.76 g, 1.41 mol), toluene (770 mL) and 20% aqueous HCl (250 mL).

Workup

customCompound IVb is obtained in 49% yield as a colourless oil

Sources & evidence

ORD record: ord-17399fc2eeea4fc3bc1448ce5460c10a
Source dataset: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08569518B2

Reaction notes

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