反应详情

To a solution of 4-chloro-2-methylpyridine (23.07 g, 181 mmol) and methyl 4-chlorobenzoate (30.8 g, 181 mmol) in dry THF (500 mL) at 0° C. was added 1 M LiHMDS in THF (63.5 g, 380 mmol) slowly via a dropping funnel. When complete, the reaction was quenched with NaHCO3 solution, concentrated under reduced pressure, and extracted with ethyl acetate. The combined organics were dried over Na2SO4, filtered and the filtrate was concentrated under reduced pressure to provide the title compound.

1. customWhen complete, the reaction was quenched with NaHCO3 solution
2. concentrationconcentrated under reduced pressure
3. extractionextracted with ethyl acetate
4. dry with materialThe combined organics were dried over Na2SO4
5. filtrationfiltered
6. concentrationthe filtrate was concentrated under reduced pressure