Hydroxyamine hydrochloride → HCID 77843991, compound

HRID 1048861Notes

Reaction equation

HRID 1048861 reaction equation
C[O-].[Na+].Cl.[NH2:5][OH:6].[C:7](/[N:9]=[C:10](\SC)/[NH:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=1)#[N:8]>C(O)C>[F:19][C:18]([F:21])([F:20])[C:14]1[CH:13]=[C:12]([NH:11][C:10]2[N:9]=[C:7]([NH2:8])[O:6][N:5]=2)[CH:17]=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 10942334Sodium MethoxideHCID 178503887HCID 178503887, compound

Product 1

HCID 77843991HCID 77843991, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Sodium methanolate (9.26 ml, 4.63 mmol, Eq: 3.00) was added into a solid hydroxylamine hydrochloride (322 mg, 4.63 mmol, Eq: 3.00) at rt. Stirred at rt for 0.5 hrs, a solution of (Z)-methyl N′-cyano-N-(3-(trifluoromethyl)phenyl)carbamimidothioate (400 mg, 1.54 mmol, Eq: 1.00) in ethanol was added and the mixture was heated to 63° C. overnight.

Workup

  1. temperaturethe mixture was heated to 63° C. overnight

Sources & evidence

ORD record
ord-436900bf989e4799ae1a091bb4954f31
Source dataset
uspto-grants-2016_07
Patent number
US09382218B2

Reaction notes

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