反应详情

To a solution of compound J (16 mg, 0.047 mmol) and 5-hydroxy-2-methylpyrimidine (6.2 mg, 0.056 mmol) in THF (1 mL) cooled to 0° C. was added triphenylphosphine (27.1 mg, 0.10 mmol) and di-tert-butylazodicarboxylate (17.3 mg, 0.075 mmol). The reaction was concentrated to dryness after 16 hours of stirring. Purification by reverse phase HPLC afforded 20 mg (98%) of the title compound. ES-MS [M+1]+: 434.3.

1. concentrationThe reaction was concentrated to dryness after 16 hours
2. customPurification by reverse phase HPLC