Butyl vinyl ether → HCID 13877170, compound

Temperature

90 °C

Methyl 4-bromo-3-methoxybenzoate (0.53 g, 2.2 mmol), 1,3-bis(diphenylphosphino)propane (0.050 g, 0.12 mmol), sodium carbonate (0.510 g, 4.81 mmol) and palladium (II) acetate (0.024 g, 0.11 mmol) were combined in a 5 mL microwave vial. The vial was sealed and purged with argon. Methanol (2.50 mL, 61.7 mmol) and n-butyl vinyl ether (1.12 mL, 8.74 mmol) were added by syringe, and the mixture was sonicated under argon flow for several minutes, then heated to 90° C. over night. Upon cooling to room temperature, celite (1 g) was added. The mixture was diluted with methanol (5 mL) and the slurry was then filtered. The filter cake was washed with methanol and to the pale red/brown methanolic filtrate was added 6M aqueous HCl (2.5 mL). The solution turned yellow and then turbid white over stirring at room temperature (0.5 h). The solvent was removed under reduced pressure and the residue obtained was partitioned between ethyl acetate (50 mL) and half-saturated aqueous sodium bicarbonate solution (25 mL). The aqueous phase was extracted with ethyl acetate (30 mL). The organic extracts were combined, washed with brine, dried over sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel chromatography (15-85% EtOAc/hexanes gradient) to afford the title compound (0.396 g, 87%). LC-MS: (FA) ES+ 209; 1H NMR (300 MHz, DMSO) δ 7.69-7.53 (m, 3H), 3.94 (s, 3H), 3.88 (s, 3H), 2.54 (s, 3H).

1. customThe vial was sealed
2. custompurged with argon
3. customthe mixture was sonicated under argon flow for several minutes
4. temperatureUpon cooling to room temperature
5. additioncelite (1 g) was added
6. filtrationthe slurry was then filtered
7. washThe filter cake was washed with methanol and to the pale red/brown methanolic filtrate
8. additionwas added 6M aqueous HCl (2.5 mL)
9. customThe solvent was removed under reduced pressure
10. customthe residue obtained
11. customwas partitioned between ethyl acetate (50 mL) and half-saturated aqueous sodium bicarbonate solution (25 mL)
12. extractionThe aqueous phase was extracted with ethyl acetate (30 mL)
13. washwashed with brine
14. dry with materialdried over sodium sulfate
15. filtrationfiltered
16. concentrationconcentrated under reduced pressure
17. customThe residue was purified by silica gel chromatography (15-85% EtOAc/hexanes gradient)

ORD record

ord-87364acfce584bd280066f3618423dcc

Source dataset

uspto-grants-2016_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09382197B2