反应详情

温度

80 °C

A solution of 2-bromo-5-((2-chloropyridin-4-yl)oxy)pyrazine (1.2 g, 4.19 mmol) in dioxane (20 mL) was degassed, treated with acetamide (0.495 g, 8.38 mmol), Cs2CO3 (2.05 g, 6.28 mmol), X-Phos (0.200 g, 0.419 mmol) and Pd2(dba)3 (0.192 g, 0.209 mmol) and heated at 80° C. for 3 h. The mixture was cooled to RT and diluted with EtOAc. The solids were removed via filtration through diatomaceous earth, rinsed well with EtOAc, and the filtrate washed with H2O, then brine, dried over Na2SO4, concentrated to dryness and purified via silica gel chromatography (EtOAc/Hex) to afford N-(5-((2-chloropyridin-4-yl)oxy)pyrazin-2-yl)acetamide (0.35 g, 31%). MS (ESI) m/z: 265.0 (M+H+).

1. temperatureThe mixture was cooled to RT
2. customThe solids were removed via filtration through diatomaceous earth
3. washrinsed well with EtOAc
4. washthe filtrate washed with H2O
5. dry with materialbrine, dried over Na2SO4
6. concentrationconcentrated to dryness
7. custompurified via silica gel chromatography (EtOAc/Hex)