反应详情

温度

130 °C

Under a nitrogen atmosphere, to a solution of 3-(2-fluoro-5-methoxyphenyl)-6-methoxy-2-neopentylpyridine (3.97 g) in DMF (10 mL) was added pyridinium chloride (7.56 g) at room temperature, and the mixture was stirred at 130° C. for 30 min. To the reaction mixture was added 1N hydrochloric acid at 0° C., and the resulting white precipitate was collected by filtration. The crude crystals were washed with water and hexane to give the title compound (3.64 g) as a white amorphous solid.

1. filtrationthe resulting white precipitate was collected by filtration
2. washThe crude crystals were washed with water and hexane