HCID 117760182, compound → HCID 117759897, compound

HRID 1049397Notes

Reaction equation

HRID 1049397 reaction equation
C([O:8][C:9]1[CH:14]=[C:13]([O:15]CC2C=CC=CC=2)[CH:12]=[CH:11][C:10]=1[C:23]1[CH:28]=[C:27]([O:29][CH3:30])[CH:26]=[CH:25][C:24]=1[F:31])C1C=CC=CC=1>C1COCC1.[Pd]>[F:31][C:24]1[CH:25]=[CH:26][C:27]([O:29][CH3:30])=[CH:28][C:23]=1[C:10]1[C:9]([OH:8])=[CH:14][C:13]([OH:15])=[CH:12][CH:11]=1

Participants

4

Reactant 1

HCID 117760182HCID 117760182, compound

Product 1

HCID 117759897HCID 117759897, compoundYield 161.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 2,4-bis(benzyloxy)-2′-fluoro-5′-methoxy-1,1′-biphenyl (23.9 g) in THF (300 mL) was added 10% palladium-activated carbon (9.60 g) and, under a hydrogen atmosphere, the mixture was stirred at room temperature for 2 hr. The reaction mixture was filtered through celite, and the filtrate was concentrated under reduced pressure to give the title compound (21.8 g) as a colorless crude oil. This compound was used for the next step without further purification.

Workup

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-910089d9a9784dd690537709664339da
Source dataset
uspto-grants-2016_07
Patent number
US09382188B2

Reaction notes

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