HCID 131736022, compound → HCID 117759663, compound

HRID 1049534Notes

Reaction equation

HRID 1049534 reaction equation
[F:1][CH:2]([C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:28]=[C:27]([O:29][CH3:30])[CH:26]=[CH:25][C:24]=2[F:31])=[C:19]([CH2:32][C:33]([CH3:36])([CH3:35])[CH3:34])[N:18]=1)[CH2:3][C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:7]=[CH:8][CH:9]=1>[C].[Pd].C(OCC)(=O)C>[F:1][CH:2]([C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:28]=[C:27]([O:29][CH3:30])[CH:26]=[CH:25][C:24]=2[F:31])=[C:19]([CH2:32][C:33]([CH3:34])([CH3:36])[CH3:35])[N:18]=1)[CH2:3][C:4]1[CH:5]=[C:6]([CH2:10][CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 1

HCID 131736022HCID 131736022, compound

Product 1

HCID 117759663HCID 117759663, compoundYield 75.3%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8857Ethyl AcetateSolvent

Procedure

Under a hydrogen atmosphere, a mixture of ethyl 3-(3-(2-fluoro-2-(5-(2-fluoro-5-methoxyphenyl)-6-neopentylpyridin-2-yl)ethyl)phenyl)acrylate (119 mg), 10% palladium-carbon (50 mg) and ethyl acetate (2.0 mL) was stirred at room temperature for 1 hr. The catalyst was removed by filtration, and the filtrate was evaporated under reduced pressure to give the title compound (90 mg) as a colorless oil.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe filtrate was evaporated under reduced pressure

Sources & evidence

ORD record
ord-e67343c4ef394f5cba04132815096972
Source dataset
uspto-grants-2016_07
Patent number
US09382188B2

Reaction notes

Loading…