Sodium Hydroxide → HCID 117759797, compound

HRID 1049535Notes

Reaction equation

HRID 1049535 reaction equation
[F:1][CH:2]([C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:28]=[C:27]([O:29][CH3:30])[CH:26]=[CH:25][C:24]=2[F:31])=[C:19]([CH2:32][C:33]([CH3:36])([CH3:35])[CH3:34])[N:18]=1)[CH2:3][C:4]1[CH:5]=[C:6]([CH2:10][CH2:11][C:12]([O:14]CC)=[O:13])[CH:7]=[CH:8][CH:9]=1.[OH-].[Na+]>C1COCC1.CO>[CH3:34][C:33]([CH3:36])([CH3:35])[CH2:32][C:19]1[N:18]=[C:17]([CH:2]([F:1])[CH2:3][C:4]2[CH:5]=[C:6]([CH2:10][CH2:11][C:12]([OH:14])=[O:13])[CH:7]=[CH:8][CH:9]=2)[CH:22]=[CH:21][C:20]=1[C:23]1[CH:28]=[C:27]([O:29][CH3:30])[CH:26]=[CH:25][C:24]=1[F:31]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 117759663HCID 117759663, compound

Product 1

HCID 117759797HCID 117759797, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of ethyl 3-(3-(2-fluoro-2-(5-(2-fluoro-5-methoxyphenyl)-6-neopentylpyridin-2-yl)ethyl)phenyl)propanoate (90 mg) in THF (2.0 mL) and methanol (1.0 mL) was added 1N aqueous sodium hydroxide solution (2.0 mL), and the mixture was stirred at room temperature for 30 min. To the reaction mixture was added, at room temperature, 1N hydrochloric acid (2.0 mL), and the mixture was extracted with ethyl acetate.

Workup

  1. additionTo the reaction mixture was added, at room temperature
  2. extraction1N hydrochloric acid (2.0 mL), and the mixture was extracted with ethyl acetate

Sources & evidence

ORD record
ord-40d61dd1b0434f278b96ba8902e25041
Source dataset
uspto-grants-2016_07
Patent number
US09382188B2

Reaction notes

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