Lawesson's reagent → HCID 117760193, compound

HRID 1049536Notes

Reaction equation

HRID 1049536 reaction equation
[C:1]([O:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:15]=2[F:22])=[C:10]([C:23]([NH:25][NH:26][C:27](=O)[C:28]([CH3:31])([CH3:30])[CH3:29])=O)[CH:9]=1)(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:42])=CC=1>C1COCC1>[C:1]([O:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:15]=2[F:22])=[C:10]([C:23]2[S:42][C:27]([C:28]([CH3:31])([CH3:30])[CH3:29])=[N:26][N:25]=2)[CH:9]=1)(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3]

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 117760049HCID 117760049, compound

Product 1

HCID 117760193HCID 117760193, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 2′-fluoro-5′-methoxy-2-(2-pivaloylhydrazinecarbonyl)-[1,1′-biphenyl]-4-yl pivalate (203 mg) and the Lawesson's reagent (194 mg) in THF (6.0 mL) was stirred at 80° C. for 50 min. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (196 mg) as a colorless oil.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe residue was purified by silica gel column chromatography (ethyl acetate/hexane)

Sources & evidence

ORD record
ord-8e518f92e069415997ef7c6ae7436def
Source dataset
uspto-grants-2016_07
Patent number
US09382188B2

Reaction notes

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