Hydrochloric Acid → HCID 117699115, compound

HRID 1049708Notes

Reaction equation

HRID 1049708 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([N:17]3[C:23](=[O:24])[CH2:22][C:21](=[O:25])[NH:20][C:19]4[C:26]5[C:31]([CH:32]=[CH:33][C:18]3=4)=[CH:30][CH:29]=[CH:28][CH:27]=5)=[CH:13][CH:12]=2)=[O:9])[CH:2]=1.[ClH:34]>C(Cl)(Cl)Cl.C(OCC)(=O)C>[ClH:34].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([N:17]3[C:23](=[O:24])[CH2:22][C:21](=[O:25])[NH:20][C:19]4[C:26]5[C:31]([CH:32]=[CH:33][C:18]3=4)=[CH:30][CH:29]=[CH:28][CH:27]=5)=[CH:13][CH:12]=2)=[O:9])[CH:2]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 117699116HCID 117699116, compound

Product 1

HCID 117699115HCID 117699115, compoundYield 71%

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 8857Ethyl AcetateSolvent

Procedure

5-[4-[(3-Pyridylacetyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione (6.2 mg, 0.014 mmol) was dissolved in chloroform (6 mL), the solution was added with a 4 M solution of hydrogen chloride in ethyl acetate (0.01 mL), and the solvent was evaporated under reduced pressure. The residue was concentrated from ethyl acetate under reduced pressure, and then washed with ethyl acetate to obtain the title compound (4.8 mg, yield 71%) as pale brown powder.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. concentrationThe residue was concentrated from ethyl acetate under reduced pressure
  3. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-4c6259c8be9d4f59bec54e9e00635a50
Source dataset
uspto-grants-2016_07
Patent number
US09382236B2

Reaction notes

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