Methyl iodide → HCID 117699197, compound

HRID 1049801Notes

Reaction equation

HRID 1049801 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([S:8]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([N:18]3[C:24](=[O:25])[CH2:23][C:22](=[O:26])[NH:21][C:20]4[C:27]5[C:32]([CH:33]=[CH:34][C:19]3=4)=[CH:31][CH:30]=[CH:29][CH:28]=5)=[CH:14][CH:13]=2)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[C:35](=O)([O-])[O-].[K+].[K+].CI>>[Br:1][C:2]1[CH:3]=[C:4]([S:8]([N:11]([C:12]2[CH:13]=[CH:14][C:15]([N:18]3[C:24](=[O:25])[CH2:23][C:22](=[O:26])[NH:21][C:20]4[C:27]5[C:32]([CH:33]=[CH:34][C:19]3=4)=[CH:31][CH:30]=[CH:29][CH:28]=5)=[CH:16][CH:17]=2)[CH3:35])(=[O:9])=[O:10])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 117699078HCID 117699078, compound

Product 1

HCID 117699197HCID 117699197, compoundYield 73%

Procedure

By using 3-bromo-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepin-5-yl)phenyl]benzenesulfonamide (78 mg, 0.145 mmol) obtained in Example 147, potassium carbonate (22 mg, 0.159 mmol), and methyl iodide (11 μL, 0.177 mmol), the title compound (58 mg, yield 73%) was obtained in the same manner as that of Example 152.

Sources & evidence

ORD record
ord-c188110f16c84c88ab09d369f61dafd2
Source dataset
uspto-grants-2016_07
Patent number
US09382236B2

Reaction notes

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