1,4-Dioxane → HCID 117704022, compound

HRID 1049869Notes

Reaction equation

HRID 1049869 reaction equation
C([NH:4][C:5]1[S:6][C:7]([S:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)(=[O:16])=[O:15])=[C:8]([CH3:13])[C:9]=1[C:10](N)=[O:11])(=O)C.[O:23]1CCOCC1>Cl>[NH2:4][C:5]1[S:6][C:7]([S:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)(=[O:16])=[O:15])=[C:8]([CH3:13])[C:9]=1[C:10]([OH:11])=[O:23]

Participants

4

Reactant 2

HCID 312751,4-DioxaneHCID 117703949HCID 117703949, compound

Product 1

HCID 117704022HCID 117704022, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
80 °C

Procedure

2-Acetylamino-5-benzenesulfonyl-4-methyl-thiophene-3-carboxylic acid amide (980 mg 2.9 mmol) is dissolved in a mixture of 6 M aqueous HCl and 1,4-dioxane (1:1, 10 mL). This mixture is then heated at 80° C. for 6 h, and concentrated by evaporation to yield a residue that is as such.

Workup

  1. concentrationconcentrated by evaporation
  2. customto yield a residue that

Sources & evidence

ORD record
ord-71273d99ffd944e596f5d1e9ffbadd6b
Source dataset
uspto-grants-2016_07
Patent number
US09382254B2

Reaction notes

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