Hydrochloric Acid → HCID 71268826, compound

HRID 1049968Notes

Reaction equation

HRID 1049968 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]=[C:13]([NH:22][C:23]3[CH:42]=[CH:41][C:26]([CH2:27][N:28]4[CH2:33][CH2:32][N:31](C(OC(C)(C)C)=O)[CH2:30][CH2:29]4)=[CH:25][CH:24]=3)[C:14]3[C:19](=[O:20])[NH:18][N:17]=[CH:16][C:15]=3[N:21]=2)=[CH:7][CH:6]=1)=[O:4].[ClH:43]>O1CCOCC1>[ClH:43].[O:20]=[C:19]1[NH:18][N:17]=[CH:16][C:15]2[N:21]=[C:11]([C:8]3[CH:7]=[CH:6][C:5]([C:3]([O:2][CH3:1])=[O:4])=[CH:10][CH:9]=3)[N:12]=[C:13]([NH:22][C:23]3[CH:24]=[CH:25][C:26]([CH2:27][N:28]4[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]4)=[CH:41][CH:42]=3)[C:14]1=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 71268944HCID 71268944, compound

Product 1

HCID 71268826HCID 71268826, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Tert-butyl 4-(4-(2-(4-(methoxycarbonyl)phenyl)-5-oxo-5,6-dihydropyrimido[4,5-d]pyridazin-4-ylamino)benzyl)piperazine-1-carboxylate (0.1 g, 0.175 mmol) was dissolved in dioxane.HCl (5 mL) and stirred at room temperature for 1.5 hours. The solid obtained was filtered and the residue washed with EtOAc and dried to give the desired product (40 mg).

Workup

  1. customThe solid obtained
  2. filtrationwas filtered
  3. washthe residue washed with EtOAc
  4. customdried

Sources & evidence

ORD record
ord-8aaf59ddb1b9416398f1e09f9a56650b
Source dataset
uspto-grants-2016_07
Patent number
US09382277B2

Reaction notes

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