反应详情

温度

140 °C

3.0 g of ethyl 2,4-dimethylthiazole-5-carboxylate, 7.0 g of ethylamine hydrochloride, 6.0 g of triethylamine, and 100 mL of ethanol were added into a 250 mL of high-pressure reactor. And the reaction mixture was heated to 120-160° C. and stirred for 20 to 30 hours, and then extracted with ethyl acetate, the organic layer was separated while the aqueous layer was extracted with ethyl acetate twice. The organic phases were combined, and dried over anhydrous sodium sulfate after washed with an iced aqueous sodium chloride solution twice, then remove the solvent under reduced pressure to obtain 1.5 g N-ethyl-2,4-dimethylthiazole-5-carboxamide which was used in the next step directly without purification.

1. extractionextracted with ethyl acetate
2. customthe organic layer was separated while the aqueous layer
3. extractionwas extracted with ethyl acetate twice
4. dry with materialdried over anhydrous sodium sulfate
5. washafter washed with an iced aqueous sodium chloride solution twice
6. customremove the solvent under reduced pressure