HRID1051182
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
产物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 140 °C
PROCEDURE
实验过程
To a stirred solution of 4-{6-bromo-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-N-cyclopropyl-2-methylbenzamide (30.8 mg, 0.05 mmol) in NMP (2 mL) was subsequently added 24.58 mg pyridin-4-ylboronic acid (0.2 mmol, 4 eq), 12.3 mg Pd(dppf)Cl2 (0.015 mmol, 0.3 eq) and aqueous potassium carbonate solution (1M, 150 μL) in one portion at rt. After heating for 40 min at 140° C. in a microwave oven, the mixture was filtered an subjected to preparative HPLC to yield 6.77 mg (27.95%) N-cyclopropyl-2-methyl-4-{6-(pyridin-4-yl)-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}benzamide.
WORKUP
后处理
- customat rt
- filtrationthe mixture was filtered