Hydrochloric Acid → HCID 136969441, compound

HRID 1051298Notes

Reaction equation

HRID 1051298 reaction equation
COC[O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[S:12][C:13]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[C:14]([CH3:16])[N:15]=2)=[CH:7][C:6]=1[N:22]1[CH:26]=[N:25][N:24]=[N:23]1.Cl>O1CCOCC1>[OH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[S:12][C:13]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[C:14]([CH3:16])[N:15]=2)=[CH:7][C:6]=1[N:22]1[CH:26]=[N:25][N:24]=[N:23]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131736098HCID 131736098, compound

Product 1

HCID 136969441HCID 136969441, compoundYield 85.7%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
60 °C

Procedure

A reaction mixture solution was prepared by dissolving 1.97 g of ethyl [4-(methoxymethoxy)-3-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-4-methyl-1,3-thiazole-5-carboxylate in 25 mL of 1,4-dioxane and adding 5.0 mL of 2 M hydrochloric acid was heated under stirring at 60° C. for 8 hours. After the reaction mixture solution was cooled to room temperature, the precipitated solid was filtered to obtain 1.49 g of ethyl 2-[4-hydroxy-3-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-4-methyl-1,3-thiazole-5-carboxylate.

Workup

  1. customA reaction mixture solution was prepared
  2. temperaturewas heated
  3. temperatureAfter the reaction mixture solution was cooled to room temperature
  4. filtrationthe precipitated solid was filtered

Sources & evidence

ORD record
ord-34b1b2feb01f426196bbddf2332bc25c
Source dataset
uspto-grants-2016_07
Patent number
US09388174B2

Reaction notes

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