Pyridine-2-carbonitrile → Picolinimidohydrazide

HRID 1051310Notes

Reaction equation

HRID 1051310 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]#[N:8].O.[NH2:10][NH2:11]>C(O)C.O>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7](=[N:10][NH2:11])[NH2:8]

Participants

5

Reactant 2

HCID 7522Pyridine-2-carbonitrileHCID 24654Hydrazine hydrate (1:1)

Product 1

HCID 70493Picolinimidohydrazide

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A solution of pyridine-2-carbonitrile 20 g (192 mM), hydrazine hydrate (3 eq.) in ethanol (50 ml) is stirred at room temperature for 18 hrs. Reaction mass is then diluted with water, extracted with ethyl acetate, dried over anhydrous sodium sulphate and concentrated under vacuum to yield desired compound.

Workup

  1. customReaction mass
  2. extractionextracted with ethyl acetate
  3. dry with materialdried over anhydrous sodium sulphate
  4. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-03300ad537084108b36a5a3032002521
Source dataset
uspto-grants-2016_07
Patent number
US09387204B2

Reaction notes

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