2-Aminopyrimidine → HCID 86631773, compound

HRID 1051315Notes

Reaction equation

HRID 1051315 reaction equation
Br[CH:2]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:3]([C:5]1[CH:12]=[CH:11][C:8]([CH:9]=[O:10])=[CH:7][CH:6]=1)=O.[N:19]1[CH:24]=[CH:23][CH:22]=[N:21][C:20]=1[NH2:25]>CN(C=O)C>[C:13]1([C:2]2[N:19]3[CH:24]=[CH:23][CH:22]=[N:21][C:20]3=[N:25][C:3]=2[C:5]2[CH:12]=[CH:11][C:8]([CH:9]=[O:10])=[CH:7][CH:6]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 79782-AminopyrimidineHCID 53434504HCID 53434504, compound

Product 1

HCID 86631773HCID 86631773, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

4.6 g 4-[bromo(phenyl)acetyl]benzaldehyde and 1.64 g pyrimidin-2-amine are stirred in 140 ml DMF at 90° C. for 4 h. The DMF is evaporated and the residue suspended in ethylacetate over night, collected by filtration.

Workup

  1. customThe DMF is evaporated
  2. waitthe residue suspended in ethylacetate over night
  3. filtrationcollected by filtration

Sources & evidence

ORD record
ord-6b7784d17daf4937ad2e9fdca44ad483
Source dataset
uspto-grants-2016_07
Patent number
US09387204B2

Reaction notes

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