Potassium Carbonate → HCID 86729298, compound

HRID 1051536Notes

Reaction equation

HRID 1051536 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[C:11]2[CH:12]=[C:13]([OH:17])[CH:14]=[CH:15][CH:16]=2)[CH:4]=[CH:3][CH:2]=1.Cl[CH2:19][C@H:20]1[CH2:22][O:21]1.C([O-])([O-])=O.[K+].[K+]>CC#N>[O:21]1[CH2:22][C@H:20]1[CH2:19][O:17][C:13]1[CH:12]=[C:11]([C:9]2[CH:8]=[CH:7][CH:6]=[C:5]3[C:10]=2[N:1]=[CH:2][CH:3]=[CH:4]3)[CH:16]=[CH:15][CH:14]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 2734062(-)-EpichlorohydrinHCID 20816513HCID 20816513, compound

Product 1

HCID 86729298HCID 86729298, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 3-(quinolin-8-yl)phenol (221 mg, 1 mmol) and (R)-2-(chloromethyl)oxirane (114.6 mg, 1.2 mmol) in CH3CN (10 mL) had K2CO3 (690 mg, 5 mmol) added to it. The reaction mixture was then stirred at 80° C. for 4 h. The solid was removed by filtration, the filtrate concentrated, and the crude product used in the next step without further purification. ESI-MS (m/z): 278.3 [M+1]+.

Workup

  1. additionadded to it
  2. customThe solid was removed by filtration
  3. concentrationthe filtrate concentrated
  4. customthe crude product used in the next step without further purification

Sources & evidence

ORD record
ord-9fe26d94e08e438187d630afee803d6a
Source dataset
uspto-grants-2016_07
Patent number
US09388173B2

Reaction notes

Loading…