Hydroxyamine hydrochloride → HCID 131736104, compound

HRID 1051940Notes

Reaction equation

HRID 1051940 reaction equation
[Cl:1][C:2]1[CH:9]=[C:8]([Cl:10])[CH:7]=[C:6]([O:11][CH3:12])[C:3]=1[CH:4]=O.CC([O-])=O.[Na+].Cl.[NH2:19][OH:20]>CN(C=O)C>[Cl:1][C:2]1[CH:9]=[C:8]([Cl:10])[CH:7]=[C:6]([O:11][CH3:12])[C:3]=1[CH:4]=[N:19][OH:20]

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 128028802,4-Dichloro-6-methoxybenzaldehyde

Product 1

HCID 131736104HCID 131736104, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A sol. of 2,4-dichloro-6-methoxybenzaldehyde (2.39 mmol) in 5 mL DMF was cooled to 0° C. and NaOAc (2.63 mmol) followed by hydroxylamine HCl (2.63 mmol) were added. The ice bath was removed and the reaction mixture was stirred at RT for 10 min. The mixture was diluted with EtOAc and washed once with water and brine. The comb. org. layers were dried over MgSO4 and conc. in vacuo to give the desired compound as white solid.

Workup

  1. additionwere added
  2. customThe ice bath was removed
  3. additionThe mixture was diluted with EtOAc
  4. washwashed once with water and brine
  5. dry with materiallayers were dried over MgSO4 and conc. in vacuo

Sources & evidence

ORD record
ord-48ca7b64776440fc948b10c66d7f150c
Source dataset
uspto-grants-2016_07
Patent number
US09388197B2

Reaction notes

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