Trifluoroacetic acid → HCID 131736110, compound

HRID 1052140Notes

Reaction equation

HRID 1052140 reaction equation
C(OC([N:8]1[C@H:13]([C:14](=[O:22])[NH:15][CH2:16][CH2:17][C:18]([CH3:21])([CH3:20])[CH3:19])[CH2:12][C@@H:11]2[C@H:9]1[CH2:10]2)=O)(C)(C)C.[C:23]([OH:29])([C:25]([F:28])([F:27])[F:26])=[O:24]>C(Cl)Cl>[F:26][C:25]([F:28])([F:27])[C:23]([OH:29])=[O:24].[CH3:19][C:18]([CH3:21])([CH3:20])[CH2:17][CH2:16][NH:15][C:14]([C@@H:13]1[CH2:12][C@@H:11]2[C@@H:9]([CH2:10]2)[NH:8]1)=[O:22]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 90019239HCID 90019239, compound

Product 1

HCID 131736110HCID 131736110, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (1R,3S,5R)-3-(3,3-dimethyl-butylcarbamoyl)-2-aza-bicyclo[3.1.0]hexane 2-carboxylic acid tert-butyl ester (310 mg, 1 mmol) in CH2Cl2 (8 mL) was added TFA (0.769 mL, 10 mmol) and the solution was stirred at RT for 2 h. The crude reaction mixture was concentrated under vacuum and was used without further purification in the next step. UPLC/MS: 211.3 [M+H]+; tR (HPLC conditions b): 1.07 min.

Workup

  1. customThe crude reaction mixture
  2. concentrationwas concentrated under vacuum
  3. customwas used without further purification in the next step
  4. custom1.07 min.

Sources & evidence

ORD record
ord-633da59d633d4f3799edc96b5784a682
Source dataset
uspto-grants-2016_07
Patent number
US09388199B2

Reaction notes

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