反应详情

2.00 g (9.94 mmol) of 1-amino-N-phenyl-1H-pyrrole-2-carboxamide were dissolved in 50 mL dimethylformamide. To this solution, 2.07 g (10.94 mmol) of (S)-2-(tert-butoxycarbonylamino)propanoic acid (purchased from Aldrich®, cat. no. 13,451-1) and 2.10 g (10.95 mmol) of EDC.HCl were added and the resulting reaction mixture was stirred at room temperature overnight. The solvent was then evaporated under vacuum, the residue was taken up in ethyl acetate and washed with an aqueous solution of sodium bicarbonate and brine, it was dried over magnesium sulphate, filtered and the solvent was evaporated. The product was purified by flash chromatography (0-5%, methanol-dichloromethane). 2.21 g (60% yield) of the final product were obtained as a white solid.

1. customthe resulting reaction mixture
2. customThe solvent was then evaporated under vacuum
3. washwashed with an aqueous solution of sodium bicarbonate and brine, it
4. dry with materialwas dried over magnesium sulphate
5. filtrationfiltered
6. customthe solvent was evaporated
7. customThe product was purified by flash chromatography (0-5%, methanol-dichloromethane)