Trifluoroacetic acid → HCID 118433752, compound

HRID 1052383Notes

Reaction equation

HRID 1052383 reaction equation
[O:1]=[C:2]1[C:7]2=[C:8]([S:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:9]=[CH:10][N:6]2[N:5]=[C:4]([C@@H:18]([NH:20]C(=O)OC(C)(C)C)[CH3:19])[N:3]1[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1.FC(F)(F)C(O)=O>>[NH2:20][C@H:18]([C:4]1[N:3]([C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[C:2](=[O:1])[C:7]2=[C:8]([S:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:9]=[CH:10][N:6]2[N:5]=1)[CH3:19]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 131736125(S)-tert-Butyl (1-(4-oxo-3-phenyl-5-(phenylthio)-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)carbamate

Product 1

HCID 118433752HCID 118433752, compoundYield 95.6%

Procedure

(S)-tert-Butyl (1-(4-oxo-3-phenyl-5-(phenylthio)-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)carbamate (190 mg, 0.41 mmol) was treated with trifluoroacetic acid (316 μl, 4.10 mmol) according to the method of Preparation 6 to obtain 142 mg (95% yield) of the title compound as a oil. Purity 95%.

Workup

  1. customaccording to the method of Preparation 6

Sources & evidence

ORD record
ord-b8c5cba2c05240df9adfa308bca2c746
Source dataset
uspto-grants-2016_07
Patent number
US09388189B2

Reaction notes

Loading…