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HRID1052428

反应详情

EQUATION

反应方程式

HRID 1052428 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：Oc1ccccc1S
HCID70718

Phenol, o-mercapto- (6CI,7CI,8CI)

C6H6OS

结构：C[C@H](NC(=O)OC(C)(C)C)c1nn2ccc(I)c2c(=O)n1-c1ccccc1
HCID131736123

未命名化合物

PRODUCTS

生成物

1
结构：C[C@H](NC(=O)OC(C)(C)C)c1nn2ccc(Sc3ccccc3O)c2c(=O)n1-c1ccccc1
HCID131736153

未命名化合物

收率 64%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：[Cu][I]
催化剂HCID24350

Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

CuI

PROCEDURE

实验过程

(S)-tert-Butyl (1-(5-iodo-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)carbamate (250 mg, 0.52 mmol) was treated with 2-mercaptophenol (80 μl, 0.80 mmol), potassium carbonate (110 mg, 0.8 mmol) and copper(I) iodide (150 mg, 0.79 mmol) according to the method described in Preparation 44. The crude was purified using SP1® Purification System (0%-25%, hexane-ethyl acetate) to give 252 mg (64% yield) to the title compound as an oil.

WORKUP

后处理

  1. customdescribed in Preparation 44
  2. customThe crude was purified
  3. customSP1® Purification System (0%-25%, hexane-ethyl acetate)