反应详情

温度

75 °C

(S)-2-(1-((5-(1H-Pyrazol-3-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (38 mg, 0.07 mmol) and 2-bromoethanol (15 mg, 0.12 mmol) were dissolved in DMF (1.5 ml) and cesium carbonate (102 mg, 0.31 mmol) was added. After stirring the mixture at 75° C. for 2 h, the solvent was evaporated under reduced pressure and the residue was suspended in water, basified with sodium carbonate and extracted with ethyl acetate (×3). The organic phase was successively washed with water and brine, dried over magnesium sulphate, filtered and the solvent evaporated under reduced pressure. The residue (31 mg, 96% purity) was used in the next synthetic step without further purification.

1. customthe solvent was evaporated under reduced pressure
2. extractionextracted with ethyl acetate (×3)
3. washThe organic phase was successively washed with water and brine
4. dry with materialdried over magnesium sulphate
5. filtrationfiltered
6. customthe solvent evaporated under reduced pressure
7. customThe residue (31 mg, 96% purity) was used in the next synthetic step without further purification