Triethylamine → HCID 90103295, compound

HRID 1052601Notes

Reaction equation

HRID 1052601 reaction equation
[Br:1][C:2]1[CH:10]=[C:9]([NH2:11])[CH:8]=[C:7]2[C:3]=1[CH:4]=[N:5][NH:6]2.[CH3:12][S:13](Cl)(=[O:15])=[O:14].C(N(CC)CC)C>>[Br:1][C:2]1[CH:10]=[C:9]([NH:11][S:13]([CH3:12])(=[O:15])=[O:14])[CH:8]=[C:7]2[C:3]=1[CH:4]=[N:5][NH:6]2

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 247280674-Bromo-1H-indazol-6-amine

Product 1

HCID 90103295HCID 90103295, compoundYield 61.5%

Procedure

4-Bromo-1H-indazol-6-amine (500 mg, 2.36 mmol) was treated with methanesulfonyl chloride (130 μl, 1.68 mmol) and triethylamine (49 μl, 3.55 mmol) according to the method described in Preparation 15b. The residue was purified using SP1® Purification System to give 300 mg (49% yield) of the title compound. Purity 80%.

Workup

  1. customThe residue was purified
  2. customSP1® Purification System

Sources & evidence

ORD record
ord-3020f2c059ce401a874eb1547830ad4e
Source dataset
uspto-grants-2016_07
Patent number
US09388189B2

Reaction notes

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